首页> 外文OA文献 >Bacterial Type III Secretion Systems: Specialized Nanomachines for Protein Delivery into Target Cells
【2h】

Bacterial Type III Secretion Systems: Specialized Nanomachines for Protein Delivery into Target Cells

机译:细菌III型分泌系统:专门的纳米机,用于将蛋白质输送到靶细胞中

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。
获取外文期刊封面目录资料

摘要

One of the most exciting developments in the field of bacterial pathogenesis in recent years is the discovery that many pathogens utilize complex nanomachines to deliver bacterially encoded effector proteins into target eukaryotic cells. These effector proteins modulate a variety of cellular functions for the pathogen's benefit. One of these protein-delivery machines is the type III secretion system (T3SS). T3SSs are widespread in nature and are encoded not only by bacteria pathogenic to vertebrates or plants but also by bacteria that are symbiotic to plants or insects. A central component of T3SSs is the needle complex, a supramolecular structure that mediates the passage of the secreted proteins across the bacterial envelope. Working in conjunction with several cytoplasmic components, the needle complex engages specific substrates in sequential order, moves them across the bacterial envelope, and ultimately delivers them into eukaryotic cells. The central role of T3SSs in pathogenesis makes them great targets for novel antimicrobial strategies.
机译:近年来,细菌致病领域最激动人心的发展之一是发现许多病原体利用复杂的纳米机器将细菌编码的效应蛋白递送到靶真核细胞中。这些效应蛋白可调节多种细胞功能,从而使病原体受益。这些蛋白质递送机器之一是III型分泌系统(T3SS)。 T3SS在自然界很普遍,不仅由脊椎动物或植物的致病细菌编码,而且还由与植物或昆虫共生的细菌编码。 T3SS的主要成分是针状复合物,它是一种超分子结构,可介导分泌蛋白穿过细菌包膜。针复合物与几种细胞质成分一起工作,以特定顺序依序接合特定底物,将它们移动穿过细菌包膜,最终将它们传递到真核细胞中。 T3SS在发病机理中的核心作用使其成为新型抗菌策略的重要靶标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号